Popular Searches
New Immune Response Clinical Trial
This clinical trial explores how the body’s immune system responds to flu infections — offering new insights that could help improve flu prevention and treatments.
Clinical trials are essential for advancing medical knowledge. This spotlight highlights the Flu Infection at UPHS trial (NCT06807840) led by the University of Pennsylvania. The study aims to learn how the immune system reacts when people get the flu, which affects many every year and can cause coughing, fever, and feeling tired.
Understanding new research is a top priority for patients and caregivers seeking information on treatment options, managing side effects, and exploring potential avenues for improvement. This post aims to provide a clear overview of what this trial is about and how it could potentially impact the future of Influenza care.
Influenza, commonly called the flu, is a contagious virus that causes respiratory illness. It spreads easily from person to person and causes symptoms like coughing, fever, and congestion. Current flu vaccines help protect people, but the body’s response to actual flu infections can vary. This study aims to better understand the immune responses after flu infections to improve future flu vaccines and treatments.
PubMed: This study looked at nasal fluids from children with the flu to find out which proteins are found more during infection. Researchers found ten proteins, such as PLUNC, cystatin S, and S100A9, were increased when someone was infected with the flu. Knowing about these proteins can help us better understand how the flu affects the body by looking at what's happening in the nose during illness. [1].
American Thoracic Society Journals: This research studied people with the flu and measured immune signals, called cytokines, in their nose and throat. The study found that certain molecules—MCP-3, IFN-α2, and IL-10—could predict how sick a person would get, no matter how old they were or how much virus they had. These findings mean that specific immune markers could help doctors know who might get sicker from the flu. [2].
Influenza can manifest in various ways, but some of the most common symptoms include:
These symptoms can make everyday activities hard and can vary in intensity from mild to severe. Learning more about these symptoms helps doctors develop better ways to prevent and treat the flu, as studied in the Flu Infection Study trial.
The Flu Infection Study trial is an observational study that looks at how the immune system responds to an active flu infection.
Immune imprinting is how your body remembers past flu infections or vaccinations and uses that memory to fight new flu viruses. This study wants to see whether your immune system relies more on this memory or builds new defenses when you actually get sick with the flu.
This study is designed to see how the body’s immune system reacts to flu infections, focusing on whether memory immune cells or new immune responses are triggered.
The study looks at memory immune cells—special cells that remember past flu viruses—and how they produce antibodies, which help fight infections. It also studies new immune responses that may develop during flu infections to understand how the body defends itself.
By studying immune responses after actual flu infections (not just vaccination), researchers hope to learn new details about how the body fights the flu, which could lead to better vaccines and treatments.
This observational study tracks flu patients over time to observe their immune responses naturally without giving any treatment, providing real-world insights about flu immunity.
The Flu Infection Study embodies this important role in research by providing a path to:
Clinical trials have specific criteria to ensure the safety of participants and the validity of the study results. For the Flu Infection Study trial, key eligibility criteria include:
If you qualify and join the Flu Infection Study trial, you can expect:
The duration of your participation will vary depending on the study design, but the research team will explain the full commitment before enrollment.
Like all medical interventions, participation in a clinical trial carries both potential benefits and risks.
A detailed explanation of all potential risks and benefits will be provided during the informed consent process.
The Flu Infection Study trial (NCT06807840) is currently recruiting at Penn Presbyterian Medical Center in Philadelphia, Pennsylvania, United States.
If you are interested in potentially participating, it is crucial to discuss these criteria with your healthcare provider. They can determine if you meet the specific requirements. You may share this link with your provider’s email address, or have them visit ClinQuestAi.com and type in NCT06807840.
You can also:
Remember: Deciding to participate in a clinical trial is a personal choice. It’s important to discuss all aspects of the trial with your healthcare provider to ensure it’s the right decision for your individual health situation.
All health-related content on this website, whether drafted by our team or with AI assistance, undergoes a rigorous human review process before publication. Every article is fact-checked, edited, and medically reviewed by a licensed medical professional with relevant expertise. Our goal is to provide information that is accurate, aligned with current medical consensus, empathetic, and useful for patients and caregivers. We are committed to transparency, clearly citing sources and displaying author and reviewer credentials to uphold the highest standards of E-E-A-T (Experience, Expertise, Authoritativeness, and Trustworthiness).